You'll find acetaminophen, also known as Tylenol, in medicine cabinets across the United States. It's not just Tylenol. The ubiquitous pharmaceutical is a common ingredient in OTC medications, from cough and cold medicines to allergy pills.
For decades, acetaminophen has been a go-to for physicians, and doctors worldwide consider it the safest pain and fever reducer for pregnant women. In fact, according to a 2019 study published in Jama Psychiatry, over 65% of women in the United States have used acetaminophen during pregnancy. 1
WHAT'S THE DEAL WITH ACETAMINOPHEN?
The US Food and Drug Administration lists acetaminophen in Pregnancy Category B. Pharmaceuticals put in this category have not shown a risk to fetal development. But there's a problem with these categorizations: a lack of research that includes pregnant women as subjects.
According to a 2021 New York Times Magazine article by Kim Tingley, "A 2014 review published in Frontiers in Pediatrics found that from the late 1960s through August 2013, just 1.3 percent of clinical trials focusing on how drugs move through the body included pregnant participants." 2
Tingley concludes that being excluded results in pregnant women who "must take such medications anyway, but without any data to say what dose is safest and most likely to work — a significant deficit, given that pregnancy causes the body to metabolize drugs differently." 2